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Sustained-release tablet: Hypersensitivity to metformin HCl or to any ingredient in the product.
Unstable and/or type 1 (insulin-dependent) diabetes mellitus.
History of lactic acidosis irrespective of precipitating factors.
Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Treat diabetic ketoacidosis with insulin.
Severe renal impairment (eGFR <30mL/min/1.73 m2).
Acute conditions with the potential to alter renal function such as: Dehydration due to persistent or severe diarrhea, recurrent vomiting; Severe infection; Diagnostic examinations (e.g., intravenous urography, angiography) that would involve the use of iodinated contrast agents/media.
Acute or chronic disease which may cause tissue hypoxia such as: Cardiac or respiratory failure; Recent myocardial infarction; Shock.
Acute or chronic alcoholism.
Severe liver disease.
Pregnancy or breastfeeding.
